The effect of Metformin on improving survival among obese and diabetic patients affected with COVID-19: Findings of a Meta-analysis


  • Mashail Alshehri College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  • Rand Abdullah Almohsen College of Pharmacy, University of Shaqra, Al Dawadmi, Saudi Arabia
  • Hana Mehaisen Almalki College of applied medical science, University of King Saud, Riyadh, Saudi Arabia
  • Shaimaa O. Ahmadeen Saudi Food and Drug Authority,Riyadh, Saudi Arabia
  • Alanoud Alqahtani King Faisal specialist hospital and research center pharmaceutical care services, Riyadh, Saudi Arabia
  • Njoud Alhusainan Saudi Biobank section, King Abdullah International Medical Research Center , Riyadh, Saudi Arabia
  • Raghad AlMouh College of Health and Rehabilitation Sciences, Princess Noura Bint Abdulrahman University, Riyadh, Saudi Arabia
  • Wjdan Ali AlNowaisir College of Public Health , University of Imam Abdulrahman Bin Faisal,Dammam, Saudi Arabia
  • Reema Hamad Mohammed Albulayhi Collage of pharmacy, Princess Nourah bint Abdulrahman University, Riyadh Saudi Arabia
  • Lujain A. Almazyad College of Medicine, King Saud bin Abdulaziz University for Health and Sciences.
  • Afnan Hashim Alnahari Ministry of Health- assistance agency for preventive Health- General administration for infectious diseases control Riyadh- Saudi Arabia
  • Badr Al-Khateeb King Abdullah International Medical Research Center (KAIMRC); King Saud bin Abdulaziz University for health science, Riyadh, Saudi Arabia.


Metformin, Mortality, COVID-19, Diabetes Mellitus, Meta-analysis


Background: Diabetes Mellitus is one of the major non-communicable diseases among patients suffering from COVID-19, which increases the likelihood of hospital admission mortality. While Metformin has been found effective in reducing the mortality associated with COVID-19, there is a need to update the existing meta-analyses and quantitively synthesize the findings regarding the effect of Metformin in reducing mortality.

Methods: We undertook a meta-analysis of 21 studies after searching for epidemiological studies systematically in PubMed/Medline, EMBASE, and Science Direct. We used odds ratios and their respective 95% confidence interval (CI) for a binary outcome, which was mortality, to examine the effect of Metformin on mortality. Heterogeneity was assessed using the I2 statistic and Q-test statistics. We evaluated the publication bias using a funnel plot, which was further confirmed by eager test statistics. A p-value of < 0.05 was considered statistically significant.

Results: Overall, the findings revealed that Metformin reduced mortality by about 35%, and the results were statistically significant (OR= 0.66; 95% CI 0.62 to 0.69; p<0.05). This revealed that patients who took Metformin had improved survival by more than one-third than those who were not given Metformin. We found a relatively higher heterogeneity with an I2 value of 85.60% (Chi-squared = 138.85. The inverted funnel plot for the findings for the effect of Metformin on mortality was asymmetrical with test statistics for an eager test of -3.64 and a P-value of 0.002.

Conclusion: The present updated meta-analysis revealed a positive effect of Metformin in reducing mortality among diabetic patients suffering from COVID-19. However, before implementing Metformin at a larger scale, clinicians and endocrinologists need to assess the risks versus benefits associated with Metformin for diabetic patients of COVID-19. Also, future studies are warranted to investigate the effects of Metformin for non-diabetic patients.



How to Cite

Alshehri , M., Almohsen, R., Almalki, H., Ahmadeen, S., Alqahtani, A. . ., Alhusainan, N. ., AlMouh, R. . ., AlNowaisir, W., Albulayhi, R., Almazyad, L., Alnahari, A., & Al-Khateeb, B. (2022). The effect of Metformin on improving survival among obese and diabetic patients affected with COVID-19: Findings of a Meta-analysis. Journal of Health Informatics in Developing Countries, 16(2). Retrieved from



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